- Research article
- Open Access
Quality of life in anorexia nervosa, bulimia nervosa and eating disorder not-otherwise-specified
© DeJong et al.; licensee BioMed Central Ltd. 2013
Received: 20 June 2013
Accepted: 31 October 2013
Published: 26 November 2013
This study aimed to assess differences in Quality of Life (QoL) across eating disorder (ED) diagnoses, and to examine the relationship of QoL to specific clinical features.
199 patients with a diagnosed ED completed the Clinical Impairment Assessment (CIA) [Cognitive Behavior Therapy and Eating Disorders, 315–318, 2008] and the Eating Disorders Examination (EDE) [Int J Eat Disord 6:1–8]. Differences between diagnostic groups were examined, as were differences between restrictive and binge-purge subtypes.
CIA scores and EDE scores were positively correlated and higher in groups with binge-purge behaviours. CIA scores were not correlated with BMI, illness duration or frequency of bingeing/purging behaviours, except in the binge-purge AN group, where CIA scores negatively correlated with BMI.
Patients with EDs have poor QoL and impairment increases with illness severity. Patients with binge/purge diagnoses are particularly impaired. It remains unclear which clinical features best predict the degree of impairment experienced by patients with EDs.
In recent years, the assessment of Quality of Life (QoL) in people with eating disorders (EDs) has been subject to considerable research interest. The World Health Organisation defines QoL as ‘an individual’s perception of their position in life in the context of the culture and value system in which they live and in relation to their goals, expectations, standards and concerns’ ; page 145. It is a multidimensional construct that is understood to include perceptions about various areas of life, including physical, psychological, social and emotional domains . QoL measures are beginning to be recognized as a key patient-oriented measure of outcome . To date, studies in EDs have indicated significantly reduced QoL in this patient group, to a degree that is comparable with QoL findings in various other serious illnesses and disorders, such as angina and anxiety disorders [3, 4]. Individuals with EDs seem to be particularly impaired in psychological and social domains [5, 6].
Patterns of diagnostic differences are inconsistent across studies, with some studies finding no significant differences between diagnostic groups [7, 8], some reporting lower QoL in individuals with anorexia nervosa (AN) than bulimia nervosa (BN) [9–11], and others reporting higher QoL in AN [12, 13]. However, studies that report higher QoL in AN also report seemingly contradictory findings, such as an increased presence of suicidal thoughts and self-harming behaviours in this group . It is also notable that studies finding less impairment in AN have tended to use generic, rather than ED specific measures of QoL, which - as has been hypothesized - may be less sensitive to certain aspects of impairment associated with these disorders . Inconsistencies in the differences reported across diagnostic groups may also be attributable to the presence of diagnostic subtypes. There is some evidence that individuals with bingeing and/or purging forms of AN are more impaired than individuals with restrictive AN [8, 15]. Several authors have suggested that a lack of insight into the negative impact of restrictive AN may inflate self-reported measures of QoL in this group – restrictive EDs are often experienced as ego-syntonic due to the valued weight loss associated with these disorders [13, 16].
It remains unclear how specific symptoms and behaviours associated with EDs impact on QoL. There is evidence that the presence of both bingeing [9, 17–19] and purging behaviours [14, 20, 21] negatively affect QoL in both clinical and community samples, but evidence regarding the impact of the frequency of these behaviours is sparse and contradictory [6, 19, 22, 23]. The effect of BMI on QoL is relatively unexplored, particularly in underweight ED samples , though there is some evidence that QoL falls with decreased BMI . There is similarly little evidence on the relationship between illness chronicity and QoL, though one study has found lower QoL in individuals with illness duration greater than five years compared to those ill for less than five years .
The present study used the Clinical Impairment Assessment (CIA) [25, 26], a measure of QoL specifically designed for use in ED populations. The CIA is designed to assess the perceived effects of having an ED on various domains, including social, emotional and cognitive aspects. Relevant domains were identified by clinicians and through interviews with patients diagnosed with an ED. The authors decided not to include items about possible physical effects of having an ED (e.g. feeling faint or cold, palpitations), arguing that individuals with EDs may not necessarily associate these effects with their eating behaviours. The CIA specifically assesses impairment that occurs as a result of an ED, whether stemming from eating behaviours or associated concerns about body shape. CIA scores have been shown to correlate closely with clinician ratings of psychosocial impairment, suggesting that the measure accurately captures clinically relevant information . CIA scores have also been shown to correlate with ED symptom severity , as measured by the Eating Disorder Examination Questionnaire (EDE-Q) . This supports the authors’ assertion that the CIA specifically measures impairment that is perceived as secondary to (that is it results from) an individual’s ED.
The aims of the current study were to extend previous findings with the CIA, using a large ED sample composed of a mixture of diagnoses. In particular, the study sought to increase the available data on CIA scores in individuals with AN –previous work with this measure has included only small numbers of participants with this diagnosis [26, 28] – and to consider possible differences between restrictive and binge-purge subtypes. In addition, the study aimed to examine the relationships between CIA score and clinical features including Eating Disorder Examination scores , BMI, illness duration and diagnosis. We hypothesised that individuals with a diagnosis of AN would report more impairment on the CIA than individuals with BN or EDNOS, as previous findings indicate that people with AN often report more impairment than other groups when ED-specific measures of QoL are used [11, 30]. We expected to replicate findings  of a positive correlation between CIA scores and ED severity, as measured by the EDE. We also hypothesised that CIA scores would be higher in patients with a longer duration of illness, in patients with lower BMIs and in patients with more frequent bingeing and purging behaviours.
Participants were all treatment-seeking individuals who were assessed at an outpatient ED service and recruited to take part in three clinical trials of outpatient treatments for anorexia and bulimia nervosa, recruiting from catchment area based specialist ED services and with minimal exclusion criteria [31–33]. The data reported here were collected at baseline, as part of a larger assessment battery used prior to randomising participants to a treatment condition. Participants were primarily recruited from the outpatient ED service of the South London and Maudsley NHS Foundation Trust. A small number of participants (N = 4) were recruited from other sites within London. Ethical approval for each trial was granted by a local NHS Research Ethics Committee.
Exclusion criteria were insufficient literacy or English language to complete research assessments, presence of serious physical or psychiatric co-morbidity requiring treatment in its own right (e.g. substance dependence, psychosis, diabetes), history of head injury or current pregnancy. Participants taking antidepressant medications were included, provided their dose had remained stable over the preceding four weeks.
The final sample reported here included 199 patients (N = 189 female) with a DSM-IV-TR  diagnosis of either AN (N = 84), BN (N = 49) or EDNOS (N = 66). Diagnoses were established by experienced ED clinicians during an initial clinical assessment. Due to the heterogeneity of AN and EDNOS as diagnoses, patients in these groups were also classified as having a restrictive presentation or a binge-purge presentation, as defined in [31–33]. The AN group was composed of 42 restrictive and 42 binge-purge cases; the EDNOS group was composed of 28 restrictive and 38 binge-purge cases.
A power calculation revealed that at a total sample size of 199 across the 5 groups, distributed across the groups as specified, a one-way analysis of variance will have 90% power to detect at the 0.01 level an effect size of 0.11.
Diagnosis and duration of illness were established during an initial clinical assessment. The measures described below were then administered by a researcher, as part of a larger battery of measures associated with one of the clinical trials. Height and weight were also measured during this assessment and used to calculate BMI (kg/m2).
Clinical impairment assessment (CIA)
The CIA (25,26) is a 16-item measure of functional impairment designed for use in individuals with EDs. It begins with the stem question: “Over the past 28 days, to what extent have your eating habits, exercising or feelings about your eating, shape and weight…?”. This question is followed by 16 items enquiring about different types of impairment (e.g. “… made it difficult to concentrate?”; “…made it difficult to eat out with others?”). Each item is rated on a 4-point scale from ‘not at all’ (scored as 0) to ‘a lot’ (scored as 3). Some items are marked ‘if applicable’ and can be left blank if not relevant for the participant.
The CIA is scored by adding all items to give a total score. Any missing items are pro-rated and added to this total, provided that at least 12 of the 16 items have been rated. The CIA therefore generates a single global score, with higher values indicating greater functional impairment. The maximum possible score is 48. The CIA has been shown to have satisfactory internal consistency, test-retest reliability, construct and discriminant validity and also sensitivity to change .
Eating disorder examination (EDE)
The EDE (29) is a semi-structured interview designed to assess key behaviours and cognitions associated with ED psychopathology. In common with the CIA, it focuses on the preceding 28 days. Each item of the interview is numerically scored and then used to generate four subscale scores (dietary restraint, eating concern, weight concern and shape concern). The mean of these subscale scores can also be used as a global measure of ED psychopathology. The range of possible scores in each case is 0 to 6, with higher scores indicating greater severity.
The EDE also gathers information on key ED behaviours over the preceding 28 days, including the number of objective binge episodes (OBEs), number of subjective binge episodes (SBEs) and number of episodes of self-induced vomiting. OBEs are defined as episodes in which the quantity of food eaten is objectively large and the individual experiences a loss of control while eating. In contrast, SBEs are defined as episodes in which the individual experiences a loss of control and views the amount eaten as excessive, but the amount eaten is not objectively large.
The EDE is a reliable and widely used assessment of ED symptomatology with good discriminant validity and satisfactory internal reliability .
All demographic and clinical variables were non-normally distributed and attempts to transform these variables were unsuccessful. Non-parametric analyses were therefore used and group differences examined using Kruskall Wallis tests, followed by post-hoc Mann Whitney U tests.
The distribution of the CIA scores was also non-normal. Outliers were defined as values lying more than 2.5 standard deviations from the mean, and were removed from further analyses (N = 4). CIA scores remained non-normally distributed and attempts to transform the scores were unsuccessful. Non-parametric analyses were therefore used to examine group differences in CIA scores. Kruskall Wallis tests were conducted, followed by post-hoc Mann Whitney U tests. Effect sizes were calculated using the formula r = Z/√N, then converted to Cohen’s d scores. Effect sizes are defined as small (d < 0.4), medium (0.4 ≤ d < 0.8) or large (d ≥ 0.8).
The AN and EDNOS groups were then divided into restrictive (R) and binge-purge (BP) subgroups, creating a total of five diagnostic groups (AN-R, AN-BP, EDNOS-R, EDNOS-BP, BN). Differences in demographic and clinical variables were examined using Kruskall Wallis tests and post-hoc Mann Whitney U tests. Differences in CIA scores across these groups were examined in the same way, and effect sizes calculated as described above.
Correlations between CIA scores and clinical variables were examined using Spearman’s rank correlation analyses. Analyses were conducted for the sample as a whole, and also separately for each diagnostic group and subgroup. In all cases a significance level of α = .05 was used.
Demographic and clinical characteristics: AN, BN, EDNOS
Demographic and clinical characteristics: AN, BN, EDNOS
AN (n = 84)
BN (n = 49)
EDNOS (n = 66)
Kruskall Wallis statistic
Duration of illness (yrs)
H = 100.97 p < .001
AN < EDNOS < BN
EDE global score
EDE dietary restraint
H = 9.13 p = .010
AN > BN = EDNOS
EDE eating concern
EDE weight concern
EDE shape concern
H = 23.06 p < .001
AN < EDNOS = BN
H = 46.66 p < .001
AN = EDNOS < BN
H = 6.78 p = .034
AN < BN
Self induced vomiting
H = 24.917 p < .001
AN = EDNOS < BN
The groups were therefore broadly similar in terms of age, illness duration and illness severity, with some differences in specific features that seemed consistent with the diagnostic profile of each group.
CIA scores: AN, BN, EDNOS
There was no significant difference between the AN, BN and EDNOS groups in CIA scores [H(2) = 3.96, p = .138]. The median scores for each group were: AN median = 34.0, IQR = 13.1; BN median = 34.13, IQR = 8.23; EDNOS median = 31.0, IQR = 13.68.
Demographic and clinical characteristics: restrictive and binge-purge subtypes
Demographic and clinical characteristics: restrictive and binge-purge subtypes
AN-R (n = 42)
EDNOS-R (n = 28)
AN-BP (n = 42)
EDNOS-BP (n = 38)
BN (n = 49)
Duration of illness
H = 127.08, p < .001
ANR < ANBP = EDNOSR < BN = EDNOSBP
EDE global score
H = 18.03, p = .001
EDNOSR = ANR < BN = ANBP = EDNOSBP
EDE dietary restraint
H = 16.18, p = .003
EDNOSBP = EDNOSR = BN = ANR < ANBP
EDE eating concern
H = 16.52, p = .002
EDNOSR = ANR < BN = EDNOSBP = ANBP
EDE weight concern
H = 16.87, p = .002
ANR = ANBP = EDNOSR < BN = EDNOSBP
EDE shape concern
H = 47.39, p < .001
EDNOSR = ANR = ANBP < EDNOSBP = BN
H = 93.74 p < .001
ANR = EDNOSR < ANBP = EDNOSBP < BN
H = 24.91 p < .001
ANR = EDNOSR < ANBP = BN = EDNOSBP
Self induced vomiting
H = 70.26 p < .001
ANR = EDNOSR < EDNOSBP < BN EDNOSBP = ANBP = BN
CIA scores: restrictive and binge-purge subtypes
Median CIA scores for restrictive and binge-purge subtypes
Median CIA score (IQR)
Correlations between clinical variables and CIA scores
CIA scores were correlated with the EDE global score [r = .44, p < .001], and with all EDE subscale scores – dietary restraint [r = .27, p < .001], eating concern [r = .48, p < .001], weight concern [r = .39, p < .001], and shape concern [r = .33, p < .001]. CIA scores were not correlated with duration of illness, BMI, objective or subjective binge frequency, or frequency of self-induced vomiting.
Correlations between CIA and EDE scores
Correlation with CIA score
EDE dietary restraint
EDE eating concern
EDE weight concern
EDE shape concern
Across the five diagnostic subgroups, CIA scores were positively correlated with EDE global scores, and with many of the subscale scores (see Table 4). In the AN-R, EDNOS-R, EDNOS-BP and BN groups, there were no correlations with any other clinical variables. However, in the AN-BP group there was a negative correlation between CIA score and BMI [r = −.43, p = .005] and a near-significant correlation between CIA score and objective binge frequency [r = −.30, p = .054].
In the present sample, all ED groups had very elevated CIA scores compared to previously reported population norms: Young adult women in Sweden: M = 8.3, SD = 9.4 , adolescent Fijian girls: M = 11.6, SD = 10.9) , young adult female Norwegian University students; M = 6.4, SD = 7.5 . There were no differences in CIA scores between diagnostic groups (AN, BN, EDNOS). However, when the groups were divided into restrictive and binge-purge subtypes, significant differences were found. The AN-BP group had higher CIA scores than the AN-R and EDNOS-R groups. The BN group also had higher CIA scores than the EDNOS-R group. This suggests a greater degree of functional impairment in binge-purge spectrum diagnoses, and particularly in binge-purge type AN. This finding is consistent with the fact that the binge-purge spectrum groups also seemed to have a higher degree of clinical severity than restrictive groups, as measured by the EDE global and subscale scores. The exception to this pattern was the EDE dietary restraint subscale, which was elevated in the AN-BP group alone, relative to all other diagnostic groups. Highly restrictive eating patterns therefore seem to particularly characterise individuals with an AN-BP diagnosis, which may account for their ability to maintain a low BMI (that is BMI < 17.5) despite engaging in episodes of binge eating.
In all diagnostic groups, CIA scores were positively correlated with EDE global scores and subscale scores. The prominent contribution of attitudinal disturbances to poor QoL in ED has recently also been highlighted by Latner and colleagues  in a mixed ED outpatient sample.
However, CIA scores were not correlated with other clinical variables such as BMI, illness duration or frequency of bingeing and/or purging behaviours. The exception to this pattern was the AN-BP group, for whom the CIA score was negatively correlated with BMI and with frequency of OBEs, that is for individuals with an AN-BP diagnosis, a higher BMI and more frequent OBEs were associated with reduced impairment. This suggests that, for people with AN-BP, a higher BMI acts as a protective factor, reducing the functional impairment associated with this diagnosis. It is possible that a combined effect of binge-purge behaviours and low BMI accounts for the particularly poor QoL in this group. The relationship between CIA scores and OBE frequency is surprising, given that binge eating is typically experienced by patients as highly distressing and causing significant impairment. One possibility is that calorie consumption during episodes of binge eating helps to mitigate the negative effects of extreme dietary restriction in this group. This finding was however only a statistical trend and requires further exploration to establish whether it can be reliably replicated.
In terms of prognosis and need for treatment, AN is considered to be the most severe ED. The finding that individuals with restrictive EDs, including AN, report less impairment and lower illness severity than other groups seems inconsistent with this view. One possibility is that the EDE and CIA are less sensitive to the symptoms and impairment associated with restrictive EDs. There is some evidence that the EDE is insufficiently sensitive and fails to detect all cases of AN and EDNOS , especially for adolescent samples . Previous work also suggests that EDE global scores are somewhat lower in AN than BN patient groups (MAN = 2.65, MBN = 3.07) . The ego-syntonic nature of these disorders may also play a role here; individuals who view their disorder as beneficial or rewarding are likely to report fewer distressing symptoms and less associated impairment . This may be the case for people with restrictive diagnoses, where the resulting weight loss is highly valued and ego-dystonic aspects of the illness may be less apparent. Bingeing and purging behaviours tend to be viewed as highly distressing and therefore individuals with these behaviours may be more aware of the negative impact of their ED. Alternatively, diagnostic differences in treatment seeking behaviour and access to specialist services could account for the lower severity and impairment reported by restrictive patients in this sample.
Clinical understanding suggests that chronic illnesses become more burdensome over time. It is therefore surprising that illness duration was not related to level of impairment in the present study. However, previous research suggests that people with chronic illnesses are motivated to adapt to their symptoms and this creates a complex relationship between illness chronicity and QoL . It is hypothesized that chronic illness produces a change in values and expectations that allows the individual to adapt to the functional impairment associated with his/her disorder – a change known as response shift [41–43]. Response shift could account for the lack of association found between illness chronicity and QoL in this and other studies . It has also been suggested that any relationship between illness chronicity and QoL in EDs may be obscured by fluctuations in symptom severity over time, given the remitting/relapsing nature of many EDs .
A limitation of the current study is the use of a treatment-seeking sample. Many individuals with EDs do not seek treatment from specialist services [44–47] and so findings in this sample may not generalise to other groups, such as community samples of people with EDs. Bohn and colleagues  note that it is often psychosocial impairment that leads people with EDs to seek help and so we might expect that a treatment-seeking sample will be particularly impaired.
A second limitation is the lack of a measure of comorbid anxiety and depression. High levels of anxiety and depression are common in people with EDs  and are likely to cause significant impairment. The CIA’s focus on impairment that is specifically related to ED thoughts and behaviours may limit the impact of anxiety and/or depression on our findings, but we are not able to exclude the possibility that comorbid anxiety and depression significantly affect CIA scores. One previous study in a community sample found a positive correlation between CIA scores and a measure of depression, although depression was not as strong a predictor of CIA score as were EDE-Q scores . This suggests that general distress, including depression and anxiety, may affect CIA responses – this is something that should be explored in future studies by including measures of comorbid anxiety and depression. Finally, duration of illness was determined by the clinical assessment (rather than by research interview).
Implications for future research
The present study suggests that there are differences in the degree of impairment across diagnostic groups and in particular, important differences between binge-purge and restrictive subtypes. This highlights the importance of accurately characterising ED samples and differentiating these subtypes in future QoL research. It remains unclear why individuals with restrictive EDs appear to have less severe symptoms and less associated impairment than those with binge-purge EDs. Research using a range of QoL measures could help examine the possibility that this effect is due to insensitivity of the CIA and EDE to detect disorder severity and impairment in this group. Self-report measures could also be supplemented with other indices of impairment (e.g. clinician ratings, reports from close others), in order to explore whether individuals with restrictive EDs under-report illness severity and impairment.
Further studies are needed to examine possible predictors of QoL and impairment in EDs. It seems likely that the relationships between clinical variables and impairment may be complex. For example, any link between illness duration and impairment is likely to be complicated by factors such as response shift and symptom fluctuation over time. A longitudinal approach may therefore be necessary to examine this relationship. Other variables may influence impairment in an interactive way. The particularly high degree of impairment in the binge-purge AN group, and the correlation with BMI in this group, suggests that bingeing and/or purging behaviours and BMI may have interactive or additive effects on functional impairment. Further work with large patient groups is needed to explore this possibility.
Implications for clinicians
Clinicians need to be aware of the high level of functional impairment found across the EDs, as this impairment is an important focus for intervention and may also significantly impact on factors such as readiness to change and motivation. Across ED diagnoses, CIA scores were very high compared to reported population norms [28, 36, 37], which suggests that individuals with EDs are severely impaired by their disorder and are very aware of the impairment they experience as a result of their ED. A focus on functional impairment in treatment may therefore help to increase motivation and readiness to change by highlighting the benefits of making changes to current eating behaviours. The CIA seems to be particularly appropriate for use in clinical work, as it was developed with input from ED patients , and therefore measures impairment in domains experienced as personally relevant to these patients.
Patients with EDs have very poor QoL compared to the general population, and individuals with EDs characterised by bingeing and/or purging behaviours seem to be particularly impaired. Impairment also seems to increase with illness severity, but does not appear to be related to the frequency of bingeing/purging behaviours, BMI or illness duration. The exception to this pattern is AN-BP patients, for whom decreased BMI is related to greater impairment. This suggests that the presence of bingeing/purging behaviour and low BMI may have interactive effects on impairment. Further work is needed to examine the role of various clinical variables in predicting the level of impairment associated with EDs and possible interactions between these variables.
This work was supported by the Biomedical Research Centre (BRC) for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King’s College London. It was also supported by research funding from the Swiss Anorexia Nervosa Foundation (Schweizerische Anorexia Nervosa Stiftung; SANS), and by a National Institute for Health Research Programme Grant for Applied Research (RP-PG-0606-1043). The views expressed herein are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
- The WHOQOL Group: The world health organisation quality of life assessment (WHOQOL): position paper from the world health organisation. Soc Sci Med. 1995, 10: 1403-1409.Google Scholar
- Garratt AM, Ruta DA, Abdalla MI, Buckingham JK, Russell IT: The SF-36 health survey questionnaire – an outcome measure suitable for routine use within the NHS?. BMJ. 1993, 306: 1440-1444.PubMed CentralView ArticlePubMedGoogle Scholar
- Keilen M, Treasure T, Schmidt U, Treasure J: Quality of life measurements in eating disorders, angina and transplant candidates: are they comparable?. J R Soc Med. 1994, 87: 441-444.PubMed CentralPubMedGoogle Scholar
- Spitzer RL, Kroenke K, Linzer M, Hahn SR, Williams JB, deGruy FV: Health related quality of life in primary care patients with mental disorders. results from the PRIME-MD 1000 study. JAMA. 1995, 274: 1511-1517.View ArticlePubMedGoogle Scholar
- Engel SG, Adair CE, Las Hayas C, Abraham S: Health-related quality of life and eating disorders: a review and update. Int J Eat Disord. 2009, 42: 179-187.View ArticlePubMedGoogle Scholar
- Jenkins PE, Hoste RR, Meyer C, Blissett JM: Eating disorders and quality of life: a review of the literature. Clin Psychol Rev. 2011, 31: 113-121.View ArticlePubMedGoogle Scholar
- de la Rie SM, Noordenbos G, van Furth EF: Quality of life and eating disorders. Qual Life Res. 2005, 14: 1511-1522.View ArticlePubMedGoogle Scholar
- Padierna A, Quintana JM, Arostegui I, Gonzalez N, Horcajo MJ: The health-related quality of life in eating disorders. Qual Life Res. 2000, 9: 667-674.View ArticlePubMedGoogle Scholar
- Abraham SF, Brown T, Boyd C, Luscombe C, Russell J: Quality of life: eating disorders. Aust N Z J Psychiatry. 2006, 30: 150-155.View ArticleGoogle Scholar
- Muñoz P, Quintana JM, Las Hayas C, Aguirre U, Padierna A, González-Torres MA: Assessment of the impact of eating disorders on quality of life using the disease-specific health-related quality of life for eating disorders (HRQoLED) questionnaire. Qual Life Res. 2009, 18: 1137-1146.View ArticlePubMedGoogle Scholar
- Bamford B, Sly R: Exploring quality of life in the eating disorders. Eur Eat Disord Rev. 2010, 18: 147-153.View ArticlePubMedGoogle Scholar
- Doll HA, Petersen SE, Stewart-Brown SL: Eating disorders and emotional and physical well-being: associations between student self-reports of eating disorders and quality of life as measured by the SF-36. Qual Life Res. 2005, 14: 705-717.View ArticlePubMedGoogle Scholar
- Mond JM, Hay PJ, Rodgers B, Owen C, Beaumont PJV: Assessing quality of life in eating disorder patients. Qual Life Res. 2005, 14: 171-178.View ArticlePubMedGoogle Scholar
- Tirico PP, Stefano SC, Blay SL: Validity studies of quality of life instruments for eating disorders: systematic review of the literature. J Nerv Ment Dis. 2010, 198: 854-859.View ArticlePubMedGoogle Scholar
- Mond JM, Rodgers B, Hay P, Korten A, Owen C, Beumont P: Disability associated with community cases of commonly occurring eating disorders. Aust N Z J Public Health. 2004, 28: 246-251.View ArticlePubMedGoogle Scholar
- Williams S, Reid M: Understanding the experience of ambivalence in anorexia nervosa: the maintainer’s perspective. Psychol Health. 2010, 2010 (25): 551-567.View ArticleGoogle Scholar
- Latner JD, Vallance JK, Buckett G: Health-related quality of life in women with eating disorders: associated with subjective and objective binge eating. J Clin Psychol Med Settings. 2008, 15: 148-153.View ArticlePubMedGoogle Scholar
- Hay P: Quality of life and bulimic eating disorder behaviors: findings from a community-based sample. Int J Eat Disord. 2003, 33: 434-442.View ArticlePubMedGoogle Scholar
- Mond JM, Hay PJ, Rodgers B, Owen C: Recurrent binge eating with and without the “undue influence of weight or shape on self-evaluation”: implications for the diagnosis of binge eating disorder. Behav Res Ther. 2006, 45: 929-938.View ArticlePubMedGoogle Scholar
- Mond JM, Hay PJ, Rodgers B, Owen C, Mitchell J: Correlates of the use of purging and non-purging methods of weight control in a community sample of women. Aust N Z J Psychiatry. 2006, 40: 136-142.View ArticlePubMedGoogle Scholar
- Mond JM, Hay PJ: Functional impairment associated with eating disorder behaviors in a community sample of women and men. Int J Eat Disord. 2007, 40: 391-398.View ArticlePubMedGoogle Scholar
- Garfinkel PE, Kennedy SH, Kaplan AS: Views on classification and diagnosis of eating disorders. Can J Psychiatry. 1995, 40: 445-456.PubMedGoogle Scholar
- Colles SL, Dixon JB, O’Brien PE: Loss of control is central to psychological disturbance associated with binge eating disorder. Obesity. 2008, 16: 608-614.View ArticlePubMedGoogle Scholar
- Padierna AA, Lopez JM, Horcajo MJ, Madrazo A, Ecenarro R: Cronicidad y calidad de vida en los trastornos de la conducta alimentaria. Anales de Psiquitria. 2004, 20: 16-21.Google Scholar
- Bohn K, Fairburn CG: The clinical impairment assessment questionnaire (CIA). Cognitive behaviour therapy and eating disorders. Edited by: Fairburn CG. 2008, New York: The Guilford Press, 315-318.Google Scholar
- Bohn K, Doll HA, Cooper Z, O’Connor M, Palmer RL, Fairburn CG: The measurement of impairment due to an eating disorder psychopathology. Behav Res Ther. 2008, 46: 1105-1110.PubMed CentralView ArticlePubMedGoogle Scholar
- Fairburn CG, Beglin SJ: Assessment of eating disorders: interview or self-report questionnaire?. Int J Eat Disord. 1994, 16: 363-370.PubMedGoogle Scholar
- Welch E, Birgegård A, Parling T, Ghaderi A: Eating disorder examination questionnaire and clinical impairment assessment questionnaire: general population and clinical norms for young adult women in Sweden. Behav Res Ther. 2011, 49: 85-91.View ArticlePubMedGoogle Scholar
- Cooper Z, Fairburn CG: The eating disorder examination: a semi-structured interview for the assessment of the specific psychopathology of eating disorders. Int J Eat Disord. 1987, 6: 1-8.View ArticleGoogle Scholar
- Turner H, Bryant-Waugh R, Peveler R: The clinical features of EDNOS: relationship to mood, health status and general functioning. Eat Behav. 2010, 11: 127-130.View ArticlePubMedGoogle Scholar
- Schmidt U, Oldershaw A, Jichi F, Sternheim L, Startup H, McIntosh V, Jordan J, Tchanturia K, Wolff G, Rooney M, Landau S, Treasure J: Out-patient psychological therapies for adults with anorexia nervosa: randomised controlled trial. Br J Psychiatry. 2012, 201: 392-399.View ArticlePubMedGoogle Scholar
- Lavender A, Startup H, Naumann U, Samarawickrema N, Dejong H, Kenyon M, Van Den Eynde F, Schmidt U: Emotional and social mind training: a randomised controlled trial of a new group-based treatment for bulimia nervosa. PLoS One. 2012, 7: e 46047-View ArticleGoogle Scholar
- Schmidt U, Renwick B, Lose A, Kenyon M, Dejong H, Broadbent H, Loomes R, Watson C, Ghelani S, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Whitehead L, Beecham J, Treasure J, Landau S: The MOSAIC study - comparison of the maudsley model of treatment for adults with anorexia nervosa (MANTRA) with specialist supportive clinical management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified, anorexia nervosa type: study protocol for a randomized controlled trial. Trials. 2013, 14 (1): 160-[Epub ahead of print] PubMed PMID: 23721562PubMed CentralView ArticlePubMedGoogle Scholar
- Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). 2000, Arlington, VA: American Psychiatric Association, FourthGoogle Scholar
- Cooper Z, Cooper PJ, Fairburn CG: The validity of the eating disorder examination and its subscales. Br J Psychiatry. 1989, 154: 807-812.View ArticlePubMedGoogle Scholar
- Becker AE, Thomas JJ, Bainivualiku A, Richards L, Navara K, Roberts AL, Gilman SE, Striegel-Moore RH: Adaptation and evaluation of the clinical impairment assessment to assess disordered eating distress in an adolescent female ethnic Fijian population. Int J Eat Disord. 2010, 43: 179-186.PubMed CentralView ArticlePubMedGoogle Scholar
- Reas DL, Rø O, Kapstad H, Lask B: Psychometric properties of the clinical impairment assessment: norms for young adult women. Int J Eat Disord. 2010, 43: 72-76.PubMedGoogle Scholar
- Latner JD, Mond JM, Vallance JK, Gleaves DH, Buckett G: Quality of life impairment and the attitudinal and behavioural features of eating disorders. J Nerv Men Dis. 2013, 597: 592-597.View ArticleGoogle Scholar
- House J, Eisler I, Simic M, Micali N: Diagnosing eating disorders in adolescents: a comparison of the eating disorder examination and the development and well-being assessment. Int J Eat Disord. 2008, 41: 535-541.View ArticlePubMedGoogle Scholar
- Cella DF: Quality of life: concepts and definition. J Pain Symptom Manage. 1994, 9: 186-192.View ArticlePubMedGoogle Scholar
- Schwartz CE, Sprangers MA: Methodological approaches for assessing response shift in longitudinal health-related quality of life research. Soc Sci Med. 1999, 48: 1531-1548.View ArticlePubMedGoogle Scholar
- Sprangers MA, Schwartz CE: Integrating response shift into health related quality of life research: a theoretical model. Soc Sci Med. 1999, 48: 1507-1515.View ArticlePubMedGoogle Scholar
- Wilson IB: Clinical understanding and clinical implications of response shift. Soc Sci Med. 1999, 48: 1577-1588.View ArticlePubMedGoogle Scholar
- Hoek HW: Incidence, prevalence and mortality of anorexia nervosa and other eating disorders. Curr Opin Psychiatry. 2006, 19: 389-394.View ArticlePubMedGoogle Scholar
- Hudson JI, Hiripi E, Pope HG, Kessler RC: The prevalence and correlates of eating disorders in the national comorbidity survey replication. Biol Psychiatry. 2007, 61: 348-358.PubMed CentralView ArticlePubMedGoogle Scholar
- Sánchez-Ortiz VC, Munro C, Stahl D, House J, Startup H, Treasure J, Williams C, Schmidt U: A randomized controlled trial of internet-based cognitive-behavioural therapy for bulimia nervosa or related disorders in a student population. Psychol Med. 2011, 41: 407-417.View ArticlePubMedGoogle Scholar
- Mond JM, Hay PJ, Rodgers B, Owen C: Health service utilization for eating disorders: findings from a community-based study. Int J Eat Disord. 2007, 40: 399-408.View ArticlePubMedGoogle Scholar
- Bulik CM: Anxiety, depression and eating disorders. Eating Disorders and Obesity. Edited by: Fairburn CG, Brownell KD. 2002, New York: The Guilford Press, 193-198. 2Google Scholar
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