Table 2 Anthropometric and hormonal parameters before and after treatment in the two groups of the study: Persistent amenorrhea group (PA-ANRec) and in Recovered menses group (RM-ANRec)
From: Mechanisms and predictors of menses resumption once normal weight is reached in anorexia nervosa
Visit 0 (baseline, before therapeutic intervention) | Visit 1 (weight recovered but persistent amenorrhea) | |||||||
|---|---|---|---|---|---|---|---|---|
PA-ANRec group | RM-ANRec group | P value | PA-ANRec group | Time P value for PA-ANRec group | RM-ANRec group | Time P value for RM-ANRec group | P value between groups | |
Age (years) | 20.9 ± 1.0 | 19.5 ± 1.2 | 0.44 | 23.0 ± 0.9 | < 0.0001 | 20.9 ± 1.1 | < 0.0001 | 0.06 |
BMI (kg/m2) | 14.9 ± 0.5 | 15.7 ± 0.3 | 0.23 | 18.7 ± 0.2 | < 0.0001 | 19.1 ± 0.2 | < 0.0001 | 0.17 |
Mean 24-h ACTH (ng/l) | 15 ± 1.4 | 15 ± 1.4 | 0.96 | 16 ± 2.4 | 0.39 | 11 ± 0.9 | 0.08 | 0.05 |
Mean 24-h Cortisol (nmol/l) | 437 ± 39 | 402 ± 17 | 0.39 | 261 ± 17 | < 0.0001 | 232 ± 13 | < 0.0001 | 0.19 |
Mean 24-h Leptin (µg /l) | 2.9 ± 0.2 | 2.5 ± 0.2 | 0.05 | 9.6 ± 0.3 | < 0.0001 | 10.3 ± 0.7 | < 0.0001 | 0.52 |
Median 24-h GH (mU/l) | 21 ± 5 | 20 ± 0.6 | 0.56 | 12.8 ± 8.6 | 0.40 | 11.6 ± 4.9 | 0.31 | 0.89 |
Prolactin (mU/l) | 288 ± 24 | 284 ± 18 | 0.12 | 230 ± 14 | 0.005 | 251 ± 16 | 0.84 | 0.35 |
Free T3 (pmol/l) | 2.5 ± 0.1 | 2.8 ± 0.1 | 0.11 | 4.9 ± 0.9 | 0.04 | 6.4 ± 0.9 | 0.006 | 0.38 |
IGF1 (µg/l) | 148 ± 24 | 166 ± 17 | 0.57 | 254 ± 18 | < 0.0001 | 287 ± 22 | < 0.0001 | 0.28 |
SDHA (µg /l) | 1051 ± 1203 | 1263 ± 180 | 0.44 | 843 ± 162 | 0.02 | 1106 ± 101 | 0.01 | 0.15 |
Normetanephrin | 1073 ± 132 | 985 ± 106 | 0.61 | 995 ± 120 | < 0.0001 | 810 ± 76 | < 0.0001 | 0.18 |
Metanephrin | 676 ± 65 | 669 ± 95 | 0.94 | 569 ± 74 | 0.08 | 545 ± 59 | 0.35 | 0.80 |
FSH (U/l) | 4.4 ± 1.2 | 3.3 ± 0.7 | 0.44 | 4.5 ± 0.4 * | 0.39 | 6.5 ± 0.4 | < 0.0001 | 0.001 |
LH (U/l) | 1.9 ± 0.7 | 0.8 ± 0.2 | 0.09 | 3.6 ± 1.2 | 0.0004 | 7.2 ± 1.0 | < 0.0001 | 0.04 |
LH 30’ (U/l) | – | – | 17.4 ± 2.5 * | – | 54.5 ± 8.7 | – | 0.0004 | |
Estradiol (ng/l) | 16.7 ± 2.7 | 10.9 ± 1.2 | 0.17 | 24.3 ± 4.5 * | 0.07 | 31.4 ± 6.2 | 0.008 | 0.39 |
Total testosterone (ng/dl) | 55 ± 9 | 46 ± 4 | 0.33 | 43 ± 4 | 0.31 | 52 ± 3 | 0.14 | 0.07 |
SHBG (nmol/l) | 92 ± 13 | 96 ± 10 | 0.80 | 59 ± 7 | 0.02 | 59 ± 5 | 0.001 | 0.97 |
Inhibin B (pg/ml) | – | – | – | 42 ± 7 * | – | 69 ± 6 | – | < 0.0001 |