Randomised controlled trial of neurostimulation for symptoms of anorexia nervosa (TRENA study): study protocol

Table 1 Outcome measures of the RCT

Measure	Mode	Baseline	Weeks 1–3	Week 4	Week 8	Weeks 10, 12, 14, 16, 18	Week 20
Core an symptoms
Eating Disorder Examination Questionnaire, EDE-Q, total score, subscales scores [30]	Electronic	✓		✓	✓	✓	✓
Weight—BMI, kg/m²		✓		✓	✓		✓
Mood
Montgomery Asberg Depression Rating Score, MADRS, total score [64]	Electronic	✓	✓	✓	✓		✓
Neurocognition
Perseveration Wisconsin Card Sorting Test, WSCT, numbers of errors [33]	Computer	✓			✓		✓
Response inhibition STROOP Colour Word Test, response time in milliseconds [70]	Computer	✓			✓		✓
Field dependence vs independence Group Embedded Figures Test, GEFT, completion time in seconds, total number of correct forms [75]	Paper	✓			✓		✓
Attention and cognitive flexibility Trail Making Test parts A & B, TMT, completion time in seconds [66]	Paper	✓			✓		✓
Psychological symptoms
Depression Anxiety and Stress Scale, DASS-21, subscales total scores [54]	Electronic	✓	✓	✓	+ Weeks 5–7✓	✓	✓
Quality of life
The Assessment of Quality of Life Instrument, AQoL-4D, total score [38]	Electronic	✓			✓		✓
Interpersonal relations
Circumplex Scales of Interpersonal Efficacy, CSIE-32, subscales total scores [52]	Electronic	✓			✓		✓
Experience of treatment OPTIONAL Semi-structured interview	Zoom				✓		✓
Assessment of blinding	Electronic				✓
Economic outcomes
Administration cost	Hospital data		✓	✓	✓	✓	✓
Medications			✓		✓		✓
Psychology sessions							✓
Length of stay				✓	✓
Readmissions							✓

ISSN: 2050-2974