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Table 1 Summary of studies reporting bone health outcomes in people with ARFID

From: Bone health in avoidant/restrictive food intake disorder: a narrative review

Authors

Study Design

Study Description

Sample Description

Sample Size

Endpoints

 

Results

 
      

HC

AN

ARFID

Schorr et al. [27]

Cross-sectional

This study investigated the prevalence of low BMD, and its determinants, in men with AN, atypical AN, and ARFID

Sex: 100% Male

Age: 18–63

Race: 100% White

Location: Massachusetts General Hospital (Boston, MA) and Denver Health Medical Center (Denver, CO)

HC: N = 48

AN: N = 26

ARFID: N = 11

Prevalence of PA spine BMD Z-score less than − 1 and − 2

 < − 1: 23%

 < − 2: 6%

 < − 1: 77%a

 < − 2: 62%a

 < − 1: 64%

 < − 2: 18%

Prevalence of total hip BMD Z-score less than − 1 and − 2

 < − 1: 8%

 < − 2: 2%

 < − 1: 50%a

 < − 2: 15%

 < − 1: 64%a

 < − 2: 9%

Prevalence of femoral neck BMD Z-score less than − 1 and − 2

 < − 1: 10%

 < − 2: 2%

 < − 1: 58%a

 < − 2: 23%a

 < − 1: 45%a

 < − 2: 0%

Alberts et al. [23]

Cross-sectional retrospective case-note review

This study compared BMD between patients with ARFID vs. AN

Sex: 19% Male

Age: 6–19

Race: 87% White

Location: Great Ormond Street Hospital (London, Eng.)

AN: N = 118

ARFID: N = 16

  

AN

ARFID

Spine (L2-L4) BMD (mean, SD)

0.92b, 0.17

0.70, 0.13

Spine (L2-L4) BMD Z-score (mean, SD)

− 1.43, 1.18

-1.88, 0.91

Spine (L2-L4) BMAD Z-score (mean, SD)

− 1.03, 1.53

-1.44, 0.88

  1. aDiffered significantly from healthy controls at P < 0.05
  2. bDiffered significantly from ARFID group at P < 0.05
  3. AN Anorexia nervosa, ARFID Avoidant/restrictive food intake disorder, BMD Bone mineral density, BMAD Bone mineral apparent density, DXA Dual-energy X-ray absorptiometry, HC Healthy control, PA Posterior-anterior, SD Standard deviation