Table 2 Genes and polymorphisms identified in the development of EDs
From: Risk factors for eating disorders: findings from a rapid review
ED | Gene | Polymorphism (allele) | Function |
|---|---|---|---|
AN | CADM1 | Â | Cell adhesion molecule 1 |
| Â | MGMT | Â | O-6-methylguanine-DNA methyltransferase |
| Â | FOXP1 | Â | Cell and tissue-specific gene transcription |
| Â | PTBP2 | Â | Polypyrimidine tract binding protein primarily expressed in the brain |
| Â | HTR1B | G861 | 5-hydroxytryptamine receptor 1B |
| Â | AGRP | rs13338499 | Agouti-related protein (appetite stimulator) |
| Â | SLC6A4 | 5-HTTLPR (S) | Serotonin transporter |
| Â | OXT-R | rs2254298 | Oxytocin receptor |
| Â | ESR1 | rs3798577 | Estrogen receptor |
| Â | EPHX2 | rs2291635 | Cholesterol metabolism/BMI |
| Â | CNTF | rs550942 | Ciliary neurotrophic factor receptor |
BN | ESR1 | rs928554 | Estrogen receptor |
| Â | CNR1 | Rs1049353 | Cannabinoid receptor |
| Â | SLC6A4 | 5-HHTLPR | Serotonin receptor |
| Â | DRD2 | Rs1800497(Taq1A) | Dopamine receptor D2 |
| Â | DRD4 | Â | Â |
| Â | COMT | Rs4680 (Va1158Met) | Catechol-O-methyltransferase |
| Â | FTO | Rs9939609 | BMI and fat mass |
| Â | NR3C1 | Bc11 | Glucocorticoid receptor |
| Â | NTRK2 | rs1078947 | Tyrosine receptor kinase (obesity and mood disorder related) |
| Â | GR | rs6198 | Glucocorticoid receptor |
BED | GHRL | Rs696217 | Ghrelin |
| Â | MC4R | Â | Melanocortin 4 receptor |
| Â | DRD2 | rs6277 | Dopamine receptor D2 |
| Â | Â | rs1800497 | Â |
| Â | ANKK1 | Rs1800497 (Taq1A) | Ankyrin repeat and kinase domain containing 1 |
| Â | DAT1 | Rs2270912 | Dopamine transporter 1 |
| Â | Â | Rs2863130 | Â |
| Â | SLC6A4 | 5-HHTLPR | Serotonin transporter |
| Â | OPRM1 | Rs1799971 (118A/G) | Dopamine receptor D2 |
| Â | BNDF | Rs6265 (Val66Met) | Brain derived neurotropic factor |
| Â | FTO | rs1558902 | BMI and fat mass |