I. | Diagnostic criteria for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS)a: |
 | a. Presence of obsessive–compulsive and/or tics disorder |
 | b. Pediatric onset symptoms must begin between 3 years—puberty |
 | c. Abrupt onset of symptoms or dramatic symptom exacerbation with a saw-tooth course |
 | d. Association with a confirmed streptococcal infection |
 | e. Association with other neuropsychiatric symptoms (e.g. choreiform movements) |
II. | Diagnostic criteria tor pediatric acute-onset syndrome (PANS)b: |
 | a. Abrupt and dramatic onset of OCD symptoms or severe restriction of food intake |
 | b. Concurrent and sudden onset of at least two of the following symptoms: |
 |  i. Anxiety |
 |  ii. Emotional lability/depression |
 |  iii. Irritability |
 |  iv. Aggression and/or oppositional behaviors |
 |  v. Behavioral (developmental) regression |
 |  vi. Deterioration in school performance |
 |  vii. Sensorimotor abnormalities |
 |  viii. Somatic signs and symptomsc |
 | c. Symptoms cannot be better explained by a known neurological or medical conditiond |