State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

Göller, Selma; Nickel, Kathrin; Horster, Isabelle; Endres, Dominique; Zeeck, Almut; Domschke, Katharina; Lahmann, Claas; Tebartz van Elst, Ludger; Maier, Simon; Joos, Andreas A. B.

doi:10.1186/s40337-022-00598-7

Journal of Eating Disorders

Table 2 Within-group differences for the contrast food > non-food (cluster-defining threshold of p_uncorr. < 0.001, k ≥ 10 voxels)

From: State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

	Hemisphere	Voxels	P_FWE-corr. Cluster	P_FWE-corr. peak voxel	MNI			T-score
	Hemisphere	Voxels	P_FWE-corr. Cluster	P_FWE-corr. peak voxel	x	y	z	T-score
Anorexia nervosa (AN)
Middle occipital gyrus	L	1086	< 0.001	0.001	− 21	− 97	8	7.05
Occipital gyrus	R			0.013	33	− 73	− 7	6.06
Lingual gyrus	R			0.015	15	− 88	− 4	5.98
	R			0.027	21	− 88	− 4	5.73
Inferior occipital gyrus	L			0.042	− 30	− 76	− 4	5.53
Insula	R	5474	< 0.001	0.004	0	− 31	35	6.63
Inferior occipital gyrus	L			0.008	− 12	20	65	6.27
Superior frontal gyrus	L			0.034	− 18	50	35	5.56
	R			0.029	15	38	50	5.70
	R			0.030	− 9	14	26	5.68
Posterior medial frontal cortex	L			0.028	− 6	53	38	5.71
	L			0.034	− 6	5	68	5.62
	R			0.044	9	17	68	5.50
Superior frontal gyrus, medial part	L			0.032	0	59	23	5.65
Middle frontal gyrus, orbital part	L			0.039	− 9	56	− 7	5.50
Medial cingulate cortex	L			0.045	− 9	− 7	32	5.49
Precuneus	L			0.046	− 6	− 52	20	5.44
Supramarginal gyrus	R	320	< 0.001	0.022	60	− 16	29	5.82
Precuneus	L	375	< 0.001	0.022	− 33	− 1	14	5.82
Postcentral gyrus	R	78	0.102	0.028^‡	− 60	− 16	26	5.70
Recovered anorexia nervosa (REC)
Insula	L	137	0.002	0.001	− 36	− 4	11	9.92
	L			0.007	− 39	5	− 13	8.38
	R	52	0.096	0.016^‡	39	− 1	2	7.86
Superior orbital gyrus	L	299	< 0.001	0.008	− 21	35	− 13	8.32
Superior frontal gyrus	L	109	0.007	0.326^†	39	− 1	2	5.67
Thalamus		104	0.008	0.387^†	0	− 7	2	5.52
Non-patients (NP)
Calcarine gyrus	R	114	0.014	0.005	18	− 94	5	6.91
Superior frontal gyrus	L	674	< 0.001	0.006	− 15	47	44	6.84
Superior occipital gyrus	L	244	< 0.001	0.012	− 18	− 91	2	6.51
Superior parietal lobule	L	196	0.001	0.012	− 24	− 76	47	6.50
Insula	L	197	0.001	0.013	− 36	− 7	11	6.47
Supramarginal gyrus	R	66	0.080	0.016^‡	− 60	− 16	32	6.36

FWE-corr. family wise error corrected, MNI standardised brain according to Montreal Neurological Institute
^†only significant at a cluster level, FWE-corrected
^‡only significant at a peak/voxel level, FWE-corrected

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ISSN: 2050-2974

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