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Fig. 1 | Journal of Eating Disorders

Fig. 1

From: How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID)

Fig. 1

Polygenic risk score (PRS) calculation to identify high risk individuals. 1. Disorder-specific GWAS on largest possible sample to identify associated alleles. 2. Derive a polygenic risk score model from the GWAS data, which incorporates associated SNPs weighted for size of effect. 3. The polygenic risk model can be applied to individuals in a target sample (independent of GWAS sample) to calculate a single polygenic risk score (PRS) that reflects genetic propensity to the phenotype. 4. Identify highest risk individuals based on genetic propensity alone, or combine PRS with information on factors such as environment, family history, and clinical measures to improve predictive ability

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