Complex functional brain network properties in anorexia nervosa

Gupta, Arpana; Bhatt, Ravi R.; Rivera-Cancel, Alannah; Makkar, Rishi; Kragel, Philip A.; Rodriguez, Thomas; Graner, John L.; Alaverdyan, Anita; Hamadani, Kareem; Vora, Priten; Naliboff, Bruce; Labus, Jennifer S.; LaBar, Kevin S.; Mayer, Emeran A.; Zucker, Nancy

doi:10.1186/s40337-022-00534-9

Journal of Eating Disorders

Table 2 Seed-to-voxel results from the sensorimotor and basal-Ganglia networks

From: Complex functional brain network properties in anorexia nervosa

Seed	Region	X	Y	Z	k (cluster size)	t-value	p-value	q -value	β value	Interpretation
Sensorimotor network (AN vs. HC)
to sensorimotor network
Right superior frontal gyrus	Right precentral gyrus	40	− 26	60	306	− 5.92	0.000008	< 0.000001	− 0.21	AN < HC
Right paracentral lobule and sulcus	Right postcentral gyrus & right precentral gyrus	40	− 20	52	281	− 5.53	< 0.000001	< 0.000001	− 0.25	AN < HC
Left central sulcus	Right supramarginal gyrus, posterior division	60	− 38	20	128	− 5.43	0.000004	0.0001	− 0.24	AN < HC
Right central sulcus	Right supramarginal gyrus, posterior division	2	− 14	66	96	− 5.4	0.000015	0.001	− 0.24	AN < HC
Left postcentral gyrus	Right supramarginal gyrus, superior division	66	− 46	26	133	− 5.34	0.000009	0.00007	− 0.21	AN < HC
Left precentral gyrus	Right supramarginal gyrus, posterior division	64	− 48	28	88	− 5.32	0.000004	0.002	− 0.22	AN < HC
Right postcentral gyrus	Right supramarginal gyrus, superior division	58	− 42	32	227	− 5.27	0.000002	< 0.000001	− 0.23	AN < HC
Left paracentral lobule and sulcus	Right precentral gyrus	40	− 20	52	139	− 5.09	0.000001	0.00005	− 0.25	AN < HC
Left central sulcus	Right precentral gyrus	10	− 18	68	69	− 5.02	0.000025	0.006	− 0.23	AN < HC
Left central sulcus	Left superior frontal gyrus	0	42	38	53	− 4.99	0.000036	0.017	− 0.25	AN < HC
Left superior part of the precentral sulcus	Left precentral gyrus	28	− 24	58	152	− 4.94	0.000035	0.00002	− 0.23	AN < HC
Left long insular gyrus and central sulcus of the insula	Left postcentral gyrus	− 42	− 30	46	37	− 4.9	0.00001	0.019	− 0.2	AN > HC
Left precentral gyrus	Left precentral gyrus	4	− 38	56	68	− 4.82	0.000016	0.005	− 0.24	AN < HC
Left superior frontal gyrus	Left precentral gyrus	− 36	− 20	46	58	− 4.8	0.000039	0.012	− 0.2	AN < HC
Left central sulcus	Left superior frontal gyrus	0	36	52	51	− 4.75	0.000016	0.017	− 0.2	AN < HC
Left hippocampus	Right supramarginal gyrus, posterior division	60	− 38	22	95	− 4.72	0.000012	0.0007	− 0.21	AN < HC
Right hippocampus	Left supramarginal gyrus, posterior division	− 60	− 40	44	48	− 4.72	0.000016	0.036	− 0.2	AN < HC
Left superior part of the precentral sulcus	Left postcentral gyrus	12	− 34	68	125	− 4.67	0.000013	0.00006	− 0.22	AN < HC
Right superior frontal gyrus	Left postcentral gyrus	− 38	− 34	46	48	− 4.67	0.000029	0.0006	− 0.21	AN < HC
Left central sulcus	Left precentral gyrus	− 6	− 24	56	40	− 4.65	0.000087	0.034	− 0.21	AN < HC
Right central sulcus	Right supramarginal gyrus, posterior division	58	− 36	22	84	− 4.65	0.000028	0.002	− 0.23	AN < HC
Left posterior ramus (or segment) of the lateral sulcus (or fissure)	Right precentral gyrus	22	− 22	60	43	− 4.48	< 0.000001	0.001	− 0.21	AN < HC
Left superior part of the precentral sulcus	Left precentral gyrus	− 4	− 20	70	59	− 4.45	0.000008	0.009	− 0.22	AN < HC
Left superior part of the precentral sulcus	Left precentral gyrus	− 50	− 14	48	51	− 4.41	0.000117	0.014	− 0.23	AN < HC
to default mode network
Left posterior ramus (or segment) of the lateral sulcus (or fissure)	Right angular gyrus	56	− 46	28	211	− 5.97	0.000004	< 0.000001	− 0.22	AN < HC
Left postcentral sulcus	Right temporal pole	46	14	− 34	51	− 5.29	0.000001	0.032	− 0.21	AN < HC
Right subcentral gyrus (central operculum) and sulci	Left cingulate gyrus, posterior division	− 62	− 58	30	54	− 5.1	0.000011	0.024	− 0.23	AN < HC
Left superior frontal gyrus	Right angular gyrus	58	− 56	36	105	− 4.92	0.000003	0.0004	− 0.24	AN < HC
Left posterior ramus (or segment) of the lateral sulcus (or fissure)	Right middle temporal gyrus, posterior division	54	− 30	− 8	50	− 4.89	0.000029	0.0006	− 0.23	AN < HC
Right superior segment of the circular sulcus of the insula	Cingulate gyrus, posterior division	0	− 28	34	104	− 4.89	0.000074	0.0006	− 0.21	AN < HC
Left thalamus	Right angular gyrus	58	− 50	28	93	− 4.88	0.000347	0.017	− 0.21	AN < HC
Right thalamus	Right angular gyrus	58	− 50	30	65	− 4.88	0.000123	0.004	− 0.19	AN < HC
Right inferior part of the precentral sulcus	Right superior temporal gyrus, posterior division	62	− 18	0	41	− 4.85	0.000012	0.048	− 0.23	AN < HC
Right superior part of the precentral sulcus	Left precuneus cortex	− 12	− 66	20	118	− 4.59	0.000016	0.0003	− 0.24	AN < HC
Right subcentral gyrus (central operculum) and sulci	Right cingulate gyrus, posterior division	4	− 28	42	50	− 4.58	0.000099	0.024	− 0.19	AN < HC
Right superior part of the precentral sulcus	Right precuneus cortex	8	− 60	16	70	− 4.52	0.0000093	0.006	− 0.22	AN < HC
Right subcentral gyrus (central operculum) and sulci	Right angular gyrus	64	− 50	28	48	− 4.45	0.000004	0.024	− 0.24	AN < HC
Right long insular gyrus and central sulcus of the insula	Left angular gyrus	− 62	− 54	32	51	− 4.3	0.000033	0.020	− 0.25	AN < HC
Left inferior segment of the circular sulcus of the insula	Cingulate gyrus, posterior division	0	− 26	36	67	− 4.19	0.000103	0.011	− 0.21	AN < HC
to emotion regulation network
Right hippocampus	Right inferior frontal gyrus, pars opercularis	48	14	18	129	− 5.92	0.000005	0.00007	− 0.19	AN < HC
Right postcentral gyrus	Left inferior frontal gyrus, pars triangularis	− 48	30	− 4	59	− 5.07	0.000024	0.013	− 0.2	AN < HC
Left postcentral sulcus	Left inferior frontal gyrus, pars triangularis	− 54	20	20	44	− 4.86	0.000005	0.043	− 0.21	AN < HC
Left central sulcus	Left paracingulate gyrus	− 6	46	12	38	− 4.65	0.000005	0.036	− 0.2	AN < HC
to central executive network
Left postcentral sulcus	Left middle frontal gyrus	− 42	6	48	71	− 6.19	0.000012	0.010	− 0.2	AN < HC
to occipital network
Left central sulcus	Left lateral occipital cortex, superior division	− 18	− 76	32	43	− 4.72	0.000022	0.030	− 0.19	AN < HC

Seed	Region	X	Y	Z	k	t	p-value	q -value	β value	Interpretation
basal ganglia network (AN vs. HC)
to sensorimotor network
Left caudate nucleus	Right postcentral gyrus	68	− 12	28	46	5.07	0.000017	0.039	0.16	AN > HC
to default mode network
Brainstem	Right angular gyrus	60	− 50	28	85	− 5.68	0.000008	0.002	− 0.19	AN < HC

Groups: Anorexia Nervosa (AN), Healthy Controls (HC)
AN Anorexia Nervosa, HC Healthy Controls
X Y Z coordinates are located in MNI Space. k: cluster size, q-value: FDR corrected p-value, β: beta

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