Complex functional brain network properties in anorexia nervosa

Table 1 Study demographics and clinical behavioral measures

	Anorexia nervosa (n = 22)	Healthy controls (n = 40)	t-value	p-value	Cohen’s D
Sample descriptive: mean (Std); range
Age in Years	17.4 (2.3); 12.3–19.9	15.1 (3.1); 10.8–20.0	3.05	0.004	0.84
Body Mass Index (BMI, kg/m²)	20.2 (2.5); 15.1–26.6^a	23.2 (5.2); 15.8–39.3^b	− 2.54	0.04	− 0.74
z-BMI	− .43 (.87); − 2.19–0.75	.60 (1.03); − 1.49 − 2.58^b
Age-adjusted Weight Percentile	38.9 (24.9); 1–77	66.0 (28.4); 7–99^b
Sex
Female	21 (95.5%)	39 (97.5%)
Male	1 (0.5%)	1 (2.5%)
Race: Count (Percentage)
White	18 (81.8%)	19 (47.5%)
Black	1 (4.5%)	16 (40.0%)
Asian	2 (9.1%)	2 (5%)
Other	1 (4.5%)	3 (7.5%)
Disorder parameters: mean (Std); range
Age of Onset in Years	13.4 (1.8); 10–17	n/a
Time to Treatment in Months	12.6 (10.9); 0–36	n/a
Length of Illness in Months	36.3 (23.6); 3–96	n/a
Time at Unhealthy Low Weight in Months	12.3 (11.2); 3–40	n/a
Current Disorder Status: Count (Percentage)^c
Acute AN Partially-Weight Restored AN Fully Weight-Restored AN	2 (9.1%) 3 (13.6%) 17 (77.3%)
Self-Report Symptom Measures^d: Mean (Std), Range
Drive for Thinness	15.05(7.9); 0–24	4.18 (5.3); 0–20	6.47	< 0.0001	1.62
Body Dissatisfaction	15.21 (7.5); 0–28	4.53 (5.0); 0–17	6.71	< 0.0001	1.68
Bulimia	3.79 (5.5); 0–19	1.41 (1.7); 0–5	2.54	0.01	0.58
Perfectionism	12.47 (6.5); 3–24	13.65 (5.8); 5–24	− 0.73	0.47	0.19
Total Score	46.53 (19.24); 4–79	23.75 (12.61); 5–53	4.34	1.41e − ⁴	1.41

Questionnaires: Body Mass Index (BMI), Age Onset, Length Illness, Time TX, Age Illness End, EDI Bulimia, EDI Body Dissatisfaction, EDI Drive for Thinness, EDI Perfectionism
N: subject number, SD standard deviation, AN Anorexia Nervosa, HC Healthy Controls, EDI Eating Disorder Inventory, TX Treatment
^aThe sample reflects individuals with a history of anorexia nervosa or atypical anorexia nervosa (in this case, a lose of 25% of body weight including crossing two weight percentiles, but being above a designated underweight BMI at baseline) at various stages of weight restoration
^bTwo individuals in the typical control group had very low weight. However, a review of their medical chart, maternal report, and self-report measures revealed no signs of an eating disorder and there was no evidence of physical symptoms that may be present if an individual was underweight (e.g., bradycardia)
^cENIGMA definitions for weight status in combination with medical chart evidence, maternal report, and self-report measures of eating disorder symptoms
^dSubscales from the Eating Disorder Inventory, 3rd edition

ISSN: 2050-2974