Table 2 Population Characteristics and Key Findings in Studies of OXTR rs53576 or rs2254298 and ED behaviour
From: Review of eating disorders and oxytocin receptor polymorphisms
Review Subsection | Authors | Sample | Summary of Study Findings - rs53576 | Summary of Study Findings - rs225498 |
|---|---|---|---|---|
OXTR Variants and ED | Connelly et al. [54] | Community sample of females | GG genotype more likely to have engaged in vomiting or laxative use as weight loss strategy | |
Micali et al. [55] | Community sample of females | A allele negatively correlated to binging/purging behaviours, GG genotype was at increased risk of engaging in binging and purging | A allele carriers at increased odds of restrictive eating/purging A allele carriers who had experienced poor maternal care at increased odds of binging purging | |
Kim et al. [56] | Females (age range not specified) with AN, BN and HC | G allele positively associated with BN, stronger association observed in those with AG genotype | ||
Acevedo et al. [57] | Adult females with AN, BN and HC | Positive association between A allele carriers of either/both SNPs and severity of ED symptomatology In those with previous AN, A allele carrier status increased severity of cognitions and eating behaviours | ||
Davis et al. [58] | Community sample of adults | No significant effects for either SNP | ||
OXTR and Brain Structure/Function | Sala et al. [59] | Adult females with, or recovered from, AN | Reduced activation of brain areas underpinning social salience and reflection observed in A allele carriers Greater negative connectivity observed in A allele carriers | |