Table 32 SSRIs for children and adolescents with Anorexia Nervosa
From: Canadian practice guidelines for the treatment of children and adolescents with eating disorders
Certainty assessment | Impact | Certainty | Importance | ||||||
|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | |||
Weight (assessed with: BMI), Core Eating disorder Symptoms (assessed with: ANIS), Depression (assessed with: DIJK) | |||||||||
1 | Case Control | serious a | not serious | not serious | not serious | none | Retrospective chart review - 19 patients on SSRIs (7 fluoxetine 20-60 mg, 8 fluvoxamine 100-150 mg, 4 sertraline 50-150 mg) compared to 13 on no medication. No differences in BMI. | ⨁◯◯◯ VERY LOW | CRITICAL |
serious a | not serious | not serious | not serious | none | No differences in core ED pathology. | ⨁◯◯◯ VERY LOW | CRITICAL | ||
serious a | not serious | not serious | not serious | none | No difference in depression scores between treated and untreated groups. | ⨁◯◯◯ VERY LOW | CRITICAL | ||
serious a | not serious | not serious | not serious | none | No difference in obsessive compulsive symptoms between treated and untreated groups. | ⨁◯◯◯ VERY LOW | CRITICAL | ||
Weight (assessed with: kg) | |||||||||
5 | Case Reports | very serious a,b | not serious | not serious | not serious | none | Five case reports (3 fluoxetine 20 mg, 2 sertraline 75-100 mg) are described in which patients had a good response to various SSRIs and gained weight. | ⨁◯◯◯ VERY LOW | CRITICAL |