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Table 2 Medical complications between AN-R and AN-BP subtypes

From: Extreme anorexia nervosa: medical findings, outcomes, and inferences from a retrospective cohort

  Cohort (N = 281) AN-R
(N = 175)
AN-BP
(N = 106)
  
N % N % Meana SDa N % Meana SDa t-testb p value
Body Temperature
 Hypothermic during stay (<  36 °C) 168 60 110 65 35.8 0.1 58 35 35.8 0.2 1.59 0.11
 Last hospital day < 36 °C      10 4–19    11 5–21 6084 0.85
 %IBW on last day < 36 °C      61.5 6.3    65.8 7.2 4.12 < .0001
Heart Rate and EKG on Admission
 Heart rate (bpm)      55.3 13.1    60.7 12.5 3.37 0.0009
 Nadir heart rate (bpm) during stay      50.1 11.8    54.3 3.9 3.06 0.002
 QTc value (ms)      421 31.4    436 37.2 1.41 < .001
 High QTc (480–500 ms) 7 3 2 29    5 71     
 Critically high QTc (>  500 ms) 7 3 3 43    4 57     
 Junctional rhythm 5 2 1 20    4 80     
 Right axis 58 21 40 69    18 31     
Liver Function
 All normal LFTs (AST < 41; ALT < 46 U/L) 85 30 36 42    49 58     
 Modestly Abnormal (up to 3x normal) 101 36 60 59    41 41     
 Severely abnormal (> 3x normal) 95 34 79 83    16 17     
 Highest AST      197 145–348    238 136–537 383 0.76
 Highest ALT      270 197–485    261 196–518 618 0.65
 Hospital day LFTs peaked      4 0–12    5 0–12 6381 0.21
Blood Glucose
 Hypoglycemia (<  3.3 mmol/L) 107 38 77 72 3.0 2.6–3.2 30 28 2.9 2.8–3.1 1637 0.45
 Last hospital day glucose < 3.3 mmol/L      2 1–2    1 0–2 1963 0.06
 Severe hypoglycemia (<  2.2 mmol/L)c 24 9 20 83 1.8 1.6–2.0 4 17 1.9 1.4–2.1   
 Last hospital day glucose < 2.2 mmol/L      1 0–3    1 0–3   
  1. AN-R Anorexia nervosa restricting subtype, AN-BP Anorexia nervosa binge-purge subtype, IBW Ideal body weight, EKG Electrocardiogram, bpm Beats per minute, LFT Liver function tests, AST Aspartate aminotransferase test, ALT Alanine aminotransferase test
  2. aMedian (IQR) for not normally distributed variables
  3. bMann-Whitney U test
  4. cThere were too few values for an analysis between AN subtypes and severe hypoglycemia