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Table 1 Case reports which have identified clubbing in patients consuming laxatives

From: Nail clubbing in laxative abuse: case report and review of the literature

Manuscript Patient details Associated Laxative FU
Silk et al. (1975) [2] 26yo F History of persisting vomiting
Normal UECs
100–200 Senna tablets/day Resolved with cessation of aperients
Prior and White (1978) [4] 24yo F Hyperventilation leading to tetany
Hypokalaemia
~ 50 Senna tablets/day Continued laxative use and clubbing
Malmquist et al. (1980) [8] 30yo F
48 kg
Aspartylglucosaminuria
Radius bones curved
Fluctuating fluid retention
Pursennid (Senna) Continued laxative use and clubbing
Levine et al. (1981) [6] 65yo F
24 kg
Hypokalaemia
Hypoalbuminaemia
Senna Resolution with cessation of senna
Armstrong et al. (1981) [9] 21yo F HOA > 3 Senna tablets/day Resolution within 6 months of ceasing senna
Fitzgerald & Redmond (1983) [7] 44yo F Hypokalaemia
Paranoid schizophrenia
4–40 Senna tablets/day Changed to Bisacodyl; clubbing “regressing”
Pines et al. (1983) [10] 28yo F
43 kg
Hypokalaemia 20–30 Senna tablets/day Continued clubbing and laxative use
35yo F
46 kg
IDDM
Smoker
Paraffin oil
Senna
Continued clubbing and laxative use
Currie et al. (2007) [3] 62yo F Mild chronic renal failure
Hypokalaemia
Senna
Lactulose
Continued clubbing and laxative use
Lim, Hooke and Kerr (2008) [5] 36yo F
BMI 17.7
Smoker
Hypercalcaemia
Hypokalaemia
Fluid retention
HOA*
50–100 Senna tablets/day Persistent despite reported reduction in Senna
  1. *This diagnosis was challenged in a Letter to the editor [11]; HOA - Hypertrophic osteoarthropathy