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Table 1 Summary of interventions: Evidence base, consistency and clinical impact

From: A systematic review and narrative synthesis of interventions for uncomplicated obesity: weight loss, well-being and impact on eating disorders

Intervention

Intervention: Specific

Evidence Base

Consistency

Clinical Impact

Dietary

Weight loss outcomes

Satisfactory

Good

Satisfactory

Increased fruit & vegetables

Satisfactory

N/A

Poor

Low energy diets (overall)

Satisfactory

Good

Poor

Low calorie

Satisfactory

Poor

Poor

High protein/low carbohydrate

Poor

N/A

Poor

Portion controlled meals

Satisfactory

Satisfactory

Satisfactory

Mental health outcomes

Poor

N/A

Satisfactory

Eating disorders outcomes

N/A

N/A

N/A

Exercise & Physical Activity

Weight loss outcomes

Good

Good

Good

Aerobic + resistance

Satisfactory

Good

Good

High intensity interval training

Satisfactory

Poor

Good

Pilates

Poor

N/A

Poor

Mental health outcomes

Poor

N/A

Satisfactory

Eating disorders outcomes

N/A

N/A

N/A

Behavioural & Psychological

Weight loss outcomes

Good

Good

Satisfactory

Behavioural weight loss

Satisfactory

Good

Good

Cognitive behavioural therapy

Good

Poor

Satisfactory

Mindfulness based therapies

Satisfactory

Poor

Poor

Acceptance based therapy

Satisfactory

N/A

Satisfactory

Motivational interviewing

Satisfactory

Poor

Satisfactory

Self-monitoring programmes

Satisfactory

Satisfactory

Satisfactory

Mental health outcomes

Satisfactory

Poor

Satisfactory

Eating disorders outcomes

Satisfactory

Good

Good

Lifestyle Interventions

Weight loss outcomes

Satisfactory

Satisfactory

Good

Diet + Exercise

Satisfactory

Good

Good

Diet + Behavioural

Satisfactory

Poor

Poor

Behavioural + Exercise

Satisfactory

Satisfactory

Good

Behavioural + Exercise + Diet

Satisfactory

Good

Good

Mental health outcomes

Satisfactory

Poor

Poor

Eating disorders outcomes

Satisfactory

N/A

Satisfactory

Pharmacotherapy

Weight loss outcomes

Excellent

Good

Good

Pharmacotherapy only

Excellent

Good

Good

Anorectics

Good

Excellent

Good

Antidiabetics

Satisfactory

N/A

Good

Antidepressants

Good

Good

Good

Anticonvulsants

Satisfactory

N/A

Satisfactory

Vitamin D & calcium

Satisfactory

Poor

Poor

Sodium alginate

Satisfactory

N/A

Poor

Fatty acid supplements

Good

Good

Poor

Dietary protein

Satisfactory

N/A

Poor

Probiotics

Satisfactory

N/A

Satisfactory

Glucomannan supplement

Satisfactory

Good

Poor

Chromium supplement

Satisfactory

N/A

Good

Yeast hydrolysate

Satisfactory

N/A

Satisfactory

Gynostemma pentaphyllum

Satisfactory

N/A

Poor

Green tea extract

Good

N/A

Poor

Pharmacotherapy + Other

Good

Satisfactory

Satisfactory

Pharmacotherapy + Diet

Satisfactory

Satisfactory

Satisfactory

Pharmacotherapy + Exercise

Satisfactory

N/A

Poor

Pharmacotherapy + Behavioural

Good

Good

Good

Pharmacotherapy

Pharmacotherapy + Diet + Exercise + Behavioural

Good

Poor

Poor

Mental health outcomes

Single interventions

Satisfactory

Poor

Poor

Combined interventions

Satisfactory

Poor

Poor

Eating disorders outcomes

Single interventions

Satisfactory

Poor

Poor

Combined interventions

Poor

N/A

N/A

Bariatric Surgery

Weight loss outcomes

Excellent

Good

Excellent

Roux-en-Y gastric bypass

Good

Satisfactory

Good

Laparoscopic sleeve gastrectomy

Good

Good

Good

Laparoscopic gastric banding

Satisfactory

Satisfactory

Good

Duodenal switch

Satisfactory

Satisfactory

Good

Mental health outcomes

Excellent

Good

Good

Eating disorders outcomes

Excellent

Satisfactory

Good

Other Interventions

Weight loss outcomes

Satisfactory

Poor

Poor

Acupressure

Poor

Good

Satisfactory

Acupuncture

Satisfactory

N/A

Good

Bright light therapy

Satisfactory

N/A

Poor

Hot bathing (+ Diet + Exercise)

Satisfactory

Poor

Satisfactory

Mental health outcomes

Poor

N/A

Poor

Eating disorders outcomes

N/A

N/A

N/A

Weight loss interventions for adolescents

Weight loss outcomes

Good

Satisfactory

Satisfactory

Diet

Satisfactory

Good

Satisfactory

Exercise (aerobic)

Satisfactory

Poor

Satisfactory

Behavioural (cognitive behavioural therapy)

Satisfactory

N/A

Satisfactory

Pharmacological (antidiabetics)

Satisfactory

Good

Good

Surgical

Good

Satisfactory

Satisfactory

Lifestyle

Satisfactory

Good

Satisfactory

Lifestyle + Pharmacological

Satisfactory

N/A

Satisfactory

Mental health outcomes

Satisfactory

Good

Satisfactory

Eating disorders outcomes

Satisfactory

Good

Good

  1. Note: The evidence base reflects the quantity and quality of available studies: Excellent = >1 SRs or >2 RCTs with low risk of bias; Good = 1–2 RCTs or 1 SR with low risk of bias; Satisfactory = SRs or RCTs with moderate risk of bias; Poor = SRs or RCTs with high risk of bias. Consistency reflects the degree to which study outcomes are consistent with each other: Excellent = all studies consistent; Good = mostly consistent; Satisfactory = some inconsistency; Poor = inconsistent; N/A = only 1 RCT. The clinical impact reflects the statistical and clinical significance of study findings: Excellent = very large; Good = substantial; Satisfactory = moderate; Poor = slight or restricted. The bolded terms (weight loss, mental health and eating disorders outcomes) reflect a summary evaluation of all interventions in each broader category