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Table 3 Comparison of Group A and Group B (patients’ characteristics)

From: Risk factors for elevated liver enzymes during refeeding of severely malnourished patients with eating disorders: a retrospective cohort study

  Group A Group B  
N = 32 N = 27
Median (IQR) Range Median (IQR) Range p valuea
Age (years) 19 (16–30) 11–46 30 (15–37) 10–54 0.322
Age of illness onset (years) 16 (15–18) 11–35 17 (13–21) 8–38 0.957
Duration of illness (years) 1.6 (0.8–12.5) 0.2–28.0 9.0 (1.0–16.0) 0.5–40.0 0.132
Duration of hospitalization (days) 46 (29–76) 15–138 48 (34–75) 23–154 0.568
BMI on admission (kg/m2) 12.2 (11.1–13.3) 9.2–14.3 12.3 (10.8–13.2) 8.1–14.9 0.831
BMI on discharge (kg/m2) 14.6 (13.6–15.0) 11.3–18.5 14.6 (13.9–16.1) 11.4–17.4 0.548
Ratio of BMI increasec 1.2 (1.1–1.3) 1.0–1.5 1.2 (1.1–1.3) 1.1–1.6 0.389
Speed of BMI increase ([kg/m2]/days)d 0.04 (0.03–0.05) 0.02–0.13 0.05 (0.03–0.07) 0.01–0.13 0.159
Minimum BMI during hospitalization (kg/m2) 12.0 (10.9–12.8) 9.2–14.0 12.2 (10.8–13.2) 8.1–14.4 0.749
Time to nadir BMI (days) 0 (0–1.8) 0–10.0 3.0 (0–6.0) 0–41.0 0.03
Initial prescribed calories (kcal/kg) 37.0 (29.7–47.2) 6.6–77.2 33.2 (27.4–48.2) 16.7–115.3 0.67
Maximum prescribed calories (kcal/kg) 71.8 (56.5–82.8) 47.1–113.1 67.2 (58.5–82.7) 43.0–116.5 0.927
Speed of caloric increase (kcal/days)e 36.6 (29.4–59.6) 0–98.3 33.3 (14.6–63.8) 0–595.0 0.721
  Frequency (%) p valueb
Early onset (<15 years old) 6 (33) 12 (67) 0.033
Peak or late onset (≥15 years old) 26 (63) 15 (37)  
  1. Patients in Group A had normal ALT levels (≤27 IU/L) during refeeding, while patients in Group B had elevated ALT levels (>27 IU/L) during refeeding
  2. ALT alanine aminotransferase, IQR interquartile range, BMI body mass index, BW body weight
  3. cRatio of BMI increase: [BMI on discharge/BMI on admission]; dSpeed of BMI increase: [(BMI on discharge–BMI on admission)/duration of hospitalization]; eSpeed of caloric increase: [(maximum prescribed calories–initial prescribed calories)/days to maximum prescribed calories]; aMann-Whitney U test; bPearson chi-square test