Risk factors for elevated liver enzymes during refeeding of severely malnourished patients with eating disorders: a retrospective cohort study

Table 1 Patients’ characteristics (N = 167)

	Median (IQR)	Range
Age (years)	22 (16–33)	10–54
Age of illness onset (years)	17 (14–20)	8–45
Duration of illness (years)	2.2 (1.0–11.0)	0.2–40.0
Duration of hospitalization (days)	58 (36–82)	15–285
BMI on admission (kg/m²)	12.2 (11.1–13.0)	8.1–14.9
BMI on discharge (kg/m²)	14.6 (13.9–15.3)	11.3–18.5
Ratio of BMI increase^a	1.2 (1.1–1.3)	1.0–1.8
Speed of BMI increase ([kg/m²]/days)^b	0.04 (0.03–0.05)	0–0.13
Minimum BMI during hospitalization (kg/m²)	11.9 (10.8–12.8)	8.1–14.6
Time to nadir BMI (days)	2 (0–6)	0–43
Initial prescribed calories (kcal/kg)	37.1 (27.7–50.3)	5.9–115.3
Maximum prescribed calories (kcal/kg)	69.6 (57.3–80.7)	29.5–125.0
Speed of caloric increase (kcal/days)^c	35.6 (19.2–54.7)	0–595.0
	Frequency (%)
AN-R	92 (55)
AN-BP	62 (37)
ARFID	8 (5)
OSFED	5 (3)
Early onset (<15 years old)	47 (28)
Peak onset (15–24 years old)	100 (60)
Late onset (≥25 years old)	20 (12)

IQR interquartile range, BMI body mass index, AN-R anorexia nervosa–restricting type, AN-BP anorexia nervosa–binge-eating/purging type, ARFID avoidant/restrictive food intake disorder, OSFED other specified feeding or eating disorder, BW body weight
^aRatio of BMI increase, BMI on discharge/BMI on admission; ^bSpeed of BMI increase: (BMI on discharge–BMI on admission)/duration of hospitalization; ^cSpeed of caloric increase: [(maximum prescribed calories–initial prescribed calories)]/days to maximum prescribed calories

ISSN: 2050-2974