From: Does anxiety improve during weight restoration in anorexia nervosa? A systematic review
Citation | Country | Data | Time of evaluations | Refeeding protocol | Other treatment components | Sample M age (SD) | N e | ED subtype (% of N ) | Treatment duration M ( SD ) | Medication use f (% of N ) | Anxiety measure (s) | BMI M ( SD ) | Anxiety change |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Brambilla et al. [51] | Italy | Longitudinal & cross sectional | T1: Ax | Slow progressive introduction of micro and macronutrientsd | CBT Psychopharmacology | Outpatient 22 (5) | 22 | AN-R (100) | x | Nortriptyline (50) | HARS | 15.9 (1.9) | F = 25.3* |
T2: 1Â month | 18.3 (1.7)* | ||||||||||||
T3: 2Â months | 14.7 (1.5) | ||||||||||||
T4: 4Â months of therapy | Fluoxetine (50) | 16.3 (2.6)* | |||||||||||
Castro-Fornieles et al. [53] | Spain | Longitudinal | T1: Ax | Initiated on 1,500Â kcal, progressive individually tailored increase to 2,500Â kcal | Biological management & nutritional rehabilitation, behavioural program, group cognitive treatment & individual/group parent counselling | Inpatient 14.4 (1.7) | 49 (1 male) | AN-R (75.5) | 29.8 (17.6) days | 24.5%g | STAI-Y | 15.5 (1.4) | Â |
T2: Dx | AN-B/P (24.5) | - State | 18.4 (0.8)* | t = 1.5 | |||||||||
T3: 9 months post Dxa |  | - Trait |  | t = 1.0 | |||||||||
Dahlgren et al. [46] | Norway | Longitudinal | T1(Inpatient): M of 36Â days post Ax | x | CRT | Inpatient & Outpatient | 20 | x | x | x | STAI | 16.81 (1.63) | Â |
T1 (Outpatient: M of 13 months post Ax | - State | 17.73 (1.39)* | t = 1.01 | ||||||||||
T2 (All): Post CRT | - Trait |  | t = 1.54 | ||||||||||
Green et al. [47] | UK (?) | Longitudinal & cross sectional | TI (Inpatient): Ax | x | x | Inpatient 26 | 12 | AN- R (100) | As previous | x | STAI | 15.03 (0.71) | NR* |
T2: After 1Â week | Â | - State | 15.02 (0.78) | ||||||||||
T3: After 12Â weeks of therapy | 17 | - Trait | 16.53 (0.65)* | ||||||||||
Controls: Over 12Â weeks at same intervals as inpatients | Controls 21 | Â | Â | 21.82 (0.53) | |||||||||
 |  | 21.82 (0.53) | |||||||||||
 |  | 21.85 (0.52) | |||||||||||
Lachish et al. [58] | Israel | Longitudinal & Cross sectional | T1: Within 7 days of Ax | x | SSRI and/or Atypical antipsychotics as required | Inpatient 15.9 (0.45) | 24 | AN-R (100) | 4.23 (4.7) months | Ax – nil | STAI | 15.5 (0.3) | NR (ns) |
Dx – 33.3%gh | State | 19.5 (0.4)* | |||||||||||
T2: Dxb | Â | Â | Â | Trait | x | ||||||||
T3: 2 – 3 yr FU | Controls | 19 |  |  |  | ||||||||
Perez et al. [48] | USA (?) | Longitudinal & cross sectional | T1: Ax | Caloric intake increased from <1200 kcal/day (T1) to ≥1800 kcal/day at T2* | x | Inpatient 15.5 | 16 | x | As previous | 56.25i | SCARED | 17.3 | NR (ns) |
T2: 14 (±2) weeks from Ax | 18.32* | ||||||||||||
 |  | Controls 16.8 | 22 | 2i | 20.7 | ||||||||
 |  | 21 | |||||||||||
Pollice et al. [45] | USA (?) | Cross-sectional | 1: Underweight | x | x | Inpatient 18 (±5) | 22 | AN-R (59%) | x | Unmedicated | HARS | 72 (6)j | F = 19.29* |
 | AN-B/P (41%) | STAI | 94 (3)j | ||||||||||
2: Short-term weight restored | - State |  | F = 25.86* | ||||||||||
3: Long-term weight restored | Outpatient 24 (±4) | 26 | - Trait | 98 (9)j | F = 22.31* | ||||||||
Controls 23 (±4) | 18 | AN-R (50%) |  | 104 (8)j |  | ||||||||
4: Controlsc | AN-B/P (50%) | Â | Â | ||||||||||
N/A | Â | Â |